Skip to product information
Jonathan L.
Verified Customer
I think this is the best probiotic I have taken so far. Really good stuff!

Seed DS-01 Daily Synbiotic - Prebiotic and Probiotic for Women & Men - Digestive Health, Gut Health, Immune Support, Bloating & Constipation Relief - Vegan & Shelf-Stable - 60 Capsules (30-Day Supply)

Seed DS-01 Daily Synbiotic - Prebiotic and Probiotic for Women & Men - Digestive Health, Gut Health, Immune Support, Bloating & Constipation Relief - Vegan & Shelf-Stable - 60 Capsules (30-Day Supply)

 (8215 Reviews)
Regular price $49.99
Regular price $49.99 Sale price $59.99
Sold out

The clinically proven, 24 strain probiotic + prebiotic for daily gut health, digestive relief, and whole body benefits.*

BUNDLE & SAVE

Benefits*

  • Reduces bloating and gas within 1 week†
  • Improves regularity and makes pooping easier within 2 weeks
  • Supports immune, skin, and heart health
  • Proven effective in 4 double-blind clinical trials

Ingredients

24 strains, 53.6 billion AFU

Third-party tested for quality, pesticides, and allergens

Vegan and low FODMAP diet compatible

No refrigeration required

View full details

THE DS-01® DIFFERENCE

Of members reported an improvement in regularity after taking DS-01®.*

Of members feel more in control of their whole body health since starting DS-01®.*

Of members have recommended DS-01® to a friend or family member.*

*Based on a survey including n=53 current Seed members evaluating self-perceived efficacy.
  • Digestive Health

    Promotes digestive health (to support healthy regularity and ease of bloating)*

    Reinforces healthy stool hydration and ease of evacuation*

    Supports gut ease from occasional gastrointestinal discomfort associated with increased intestinal transit time*

  • Gut Barrier Integrity

    Maintains healthy gut barrier function and integrity*

    Reinforces healthy tight junction in vitro*

    Supports healthy gut barrier integrity from ethanol- and endotoxin-induced (lipopolysaccharide) permeability in vitro*

  • Gut Immune Function

    Supports healthy gut immune function and 'cross-talk' between immune and intestinal cells*

    Maintains healthy immunological responses in the gastrointestinal tract*

    Supports production of short-chain fatty acids*

  • Cardiovascular Health

    Promotes heart health*

    Maintains blood cholesterol levels already in the normal range*

    Supports healthy intestinal recycling of cholesterol and bile*

  • Dermatological Health

    Promotes healthy skin*

    Reinforces healthy gut-skin axis*

  • Micronutrient Synthesis

    Supports folate (vitamin B9) production via intestinal synthesis of bioactive forms of folate*

    Supports synthesis of vitamin B12 in vitro*

    The complete probiotic that delivers results in just 7 days.

    Reduces Bloating and Gas†

    Clinically proven to reduce bloating

    Alleviates excess gas

    Eases digestive discomfort

    Supports Healthy Regularity*

    • Promotes daily poops
    • Reduces occasional constipation

    Smooths + Clears Skin*

    • Supports clear, healthy skin
    • Reduces wrinkles and signs of aging
    • Enhances the skin barrier

    Immune + Heart Support*

    • Promotes immune system resilience
    • Balances healthy cholesterol
    • Supports healthy aging

    The DS-01® Difference

    Our formulation prioritizes strain diversity and survivability, so you get clinically proven results, not empty promises.

    Our formulation prioritizes strain diversity and survivability,

    so you get clinically proven results, not empty promises.

    Dr. Zain Kassam, MD, MPH

    Chief Medical Officer, Seed Health

    24 Diverse Probiotic Strains

    Research-derived doses for microbial diversity, the foundation of a healthy gut.

    Antioxidant-Promoting Prebiotic

    Non-fiber based prebiotic (unlike many found in food or drinks) that feeds beneficial gut microbes.

    Engineered to Survive

    Proprietary ViaCap® technology safeguards probiotics during the journey to the colon.

    4 Gold-Standard Clinical Trials

    Scientifically validated by experts as a complete formulation, four different times.

    Many probiotics don’t make it to the gut alive. DS-01 does.

    PREBIOTIC OUTER
    CAPSULE
    Non- fermenting preblotlc releases In the upper Gltract.

    PROBIOTIC INNER CAPSULE Delivers live bacterla to the colon where lt's needed most.

    Strengthens your gut at the source for lasting relief.

    DS-01® outperforms other probiotics.



    DS-01®

    Others

    24 clinically studied probiotic strains

    5 or less strains, rarely tested clinically

    Engineered for precision delivery to the colon

    Rarely reaches the colon

    Third-party tested for pesticides, allergens, and heavy metals

    Rare

    Vegan, gluten- and nut-tested, low FODMAP

    Rare

    Strains that work harder for your whole body.

    Chosen for their ability to improve gut function and build whole body health.

    Gut + Immune Health Blend

    Probiotic blend for digestive health, gut barrier integrity, and healthy immune response.

    Supporting strains:

    Bifidobacterium breveSD-BR3IT.

    Ligilactobacillus salivariusSD-LS1-IT Bifidobacterium longumSD-BB536-JP

    Skin Health Blend

    Probiotic blend that improves clarity, texture, and signs of aging in 12 weeks.

    Supporting strains:

    Bifidobacterium longumSD-CECT7347-SP

    Ligilactobacillus salivariusSD-LS1-IT

    Heart Health Blend

    Supports healthy, balanced cholesterol levels.

    Supporting strains:

    Lactiplantibacillus plantarumSD-LPLDL-UK

    Bifidobacterium lactisSD-MB2409-IT

    Vegan

    Dairy-Tested

    Nut-Tested

    Sesame-Tested

    Glyphosate / AMPA-Tested

    No Preservatives

    Gluten-Tested

    Soy-Tested

    Shellfish-Tested

    Corn-Tested

    No Binders

    Prop. 65 Compliant

    Strains that work harder for your whole body.

    Chosen for their ability to improve gut function and build whole body health.

    Gut + Immune Health Blend

    Probiotic blend for digestive health, gut barrier integrity, and healthy immune response.

    Supporting strains:

    Bifidobacterium breveSD-BR3IT.

    Ligilactobacillus salivariusSD-LS1-IT Bifidobacterium longumSD-BB536-JP

    Skin Health Blend

    Probiotic blend that improves clarity, texture, and signs of aging in 12 weeks.

    Supporting strains:

    Bifidobacterium longumSD-CECT7347-SP

    Ligilactobacillus salivariusSD-LS1-IT

    Heart Health Blend

    Supports healthy, balanced cholesterol levels.

    Supporting strains:

    Lactiplantibacillus plantarumSD-LPLDL-UK

    Bifidobacterium lactisSD-MB2409-IT

    Vegan

    Soy-Tested

    Sesame-Tested

    No Binders

    Gluten-Tested

    Nut-Tested

    Corn-Tested

    No Preservatives

    Dairy-Tested

    Shellfish-Tested

    Glyphosate / AMPA-Tested

    Prop. 65 Compliant

    Bridges thefiber gap.

    Fiber is one of the hardest nutrients to incorporate into a child's diet—it can also directly impact the health of the gut microbiome.

    95% of children and adults in the US do not reach theirdaily recommended fiber intake.With 5 grams of fiber per serving, PDS-08® is a meaningful complement to a healthy diet.

    Food

    Apples

    Strawberries

    Cherries

    Bananas

    Broccoli

    Garlic

    Serving size

    1 medium w/skin

    1 cup

    10 cherries

    1 medium

    1/2 cup

    1 clove

    Fiber

    3.7g

    3.4g

    1.3g

    3.0g

    2.3g

    0.19g

    Quantity to match PDS-08®

    1.4 apples

    1.5 cups

    38 cherries

    1.7 bananas

    1.1 cups

    26.3 cloves

    Sweet Potatoes

    Almonds

    Brown Rice

    Multi-grain bread

    1 medium

    1/4 cup

    1 cup

    1 slice

    3.0g

    3.2g

    3.5g

    1.5g

    1.7 sweet potatoes

    0.4 cups

    1.4 cups

    1.4 cups

    Bridges thefiber gap.

    Fiber is one of the hardest nutrients to incorporate into a child's diet—it can also directly impact the health of the gut microbiome.

    95% of children and adults in the US do not reach theirdaily recommended fiber intake.

    With 5 grams of fiber per serving, PDS-08® is a meaningful complement to a healthy diet.

    Apples

    Strawberries

    Cherries

    Bananas

    Broccoli

    Garlic

    Sweet Potatoes

    Almonds

    Brown Rice

    Multi-grain bread

    1.4 apples

    1.5 cups

    38 cherries

    1.7 bananas

    1.1 cups

    26.3 cloves

    1.7 sweet potatoes

    0.4 cups

    1.4 cups

    3.3 slices

    Sustainably delivered, monthly.

    Our refill pouches protect your DS-01® through transit while being gentler on our Earth.

    We stand by

    our science.

    30-Day Guarantee

    If DS-01® doesn’t work for you, request a refund within 30 days of your order delivery for your money back.

    Free US Shipping

    US orders ship within 1-2 business days.International flat-rate.

    Flexible Subscription

    Easily reschedule your DS-01® deliveries or cancel your subscription any time.

    Talk With Our Team of Experts

    Our SciCare team is here to answer all of your science, health, and product-related questions.

    Composition-specific Benefits

    PDS-08® is the first 9-strain pediatric synbiotic to be studied in a double-blind, randomized 12-week trial in a pediatric population, demonstrating that it is tolerable and health-promoting for children and adolescents. The following benefits were observed in the composition as a whole:

    Easy, frequent bowel movements.

    Studied in a pediatric population1 to support digestive function and regular, healthy bowel movements in children with fewer than five bowel movements per week.2

    Increase ofBifidobacterium.

    Significantly enriches Bifidobacterium3 in the pediatric gut microbiome as demonstrated via metagenomic shotgun sequencing.4

    Promotes healthy regularity.

    Maintains healthy bowel movement regularity1 among non-constipated2 children without creating hyper-frequency of bowel movements.

    Production of Short-Chain Fatty Acidsin vitro.

    Significant increase in the concentration of SCFAs present in the colon compartment of SHIME®,5 suggesting that PDS-08® supports the production of SCFAs in the lower gut.

    Exceptionally well tolerated.

    No observed side effects or GI distress (such as pain, bloating, gas, diarrhea1) as commonly reported with many fiber-based dietary supplements, probiotics, and high-dose fermentable prebiotics.

    Directions for Use

    Take 1 capsule daily for the first three days.

    On day four (or when you’re ready), increase to the full dose of 2 capsules at once, daily. Ideally, take both capsules on an empty stomach or at least 10 minutes prior to a meal.

    Fig. 1— Acclimation protocol

    Just as with any new diet, product, or change, you may experience a temporary acclimation period—some gastrointestinal discomfort, abdominal tightness, mild nausea, or changes in your stool. This can be very normal. In fact, an immediate physiological reaction is a sign that our probiotics are viable and attuning to your system. Any discomfort should subside within the first few weeks of consistent use.

    If the discomfort does not subside, you may try experimenting with your DS-01® use. Try taking the capsules with food or one capsule in the morning and one in the evening.

    Digestive Survivability Testing (SHIME®)

    To evaluate the survival of our probiotics, we test with a Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)—the closest system developed to model human digestion and the gut. It recreates the physiological conditions and biological processes (food uptake, peristalsis, digestive enzymes, pancreatic and bile acids, and time spent in each step) representative of the human gastrointestinal tract.

    Fig. 3— The SHIME® Process

    At the three hour mark of incubation, the ViaCap® delivered a maximal release of probiotics maintaining the full value of the starting dose (10.57 log vs 10.60 log, or about 100%), indicating viability through the end of the small intestine for delivery into the colon. The ViaCap® was engineered for a precision release of the contents of the inner, probiotic capsule, through the small intestine, resulting in full delivery of label potency prior to entering the colon chamber.

    Questions?We’re here to help.

    When will I feel something?

    It is normal to feel effects in the digestive tract in as little as 24-48 hours. Other longer term benefits like cardiovascular health and gut immune function may take longer. As long as you continue your daily intake, those beneficial microbes are doing their work inside to program, sustain, and enhance your health.

    How do I take DS-01® Daily Synbiotic?

    Adults—take 2 capsules daily, all at once. Preferably on an empty stomach to limit exposure to digestive enzymes and bile salts. However, you know your body best—if it’s more comfortable for you to take with food, please feel free to do so.

    Why should I take DS-01® Daily Synbiotic?

    You are home to a community of trillions of microorganisms, including 38,000,000,000,000 bacteria that live in and on you. They perform critical functions like digesting food, managing inflammation, and synthesizing key vitamins, metabolites and neurotransmitters. This is the microbiome. By supplementing your gut microbial makeup, DS-01® provides benefits for both digestive and whole body health.

    Can I take this with other supplements? What about medications?

    Can I take this with other supplements? What about medications?

    What does DS-01® Daily Synbiotic do?

    DS-01® contains probiotic strains that have been clinically and scientifically studied to provide benefits around gastrointestinal function, skin health, heart health, gut immune function, gut barrier integrity, and micronutrient synthesis.

    Do I need to refrigerate my DS-01® Daily Synbiotic

    No refrigeration necessary.

    Do I have to sign up for a subscription?

    Yes. We believe that probiotics and prebiotics, alongside diet, nutrition, exercise, and lifestyle, are cornerstone tools to building foundational health. Clinical research shows that continuous, daily intake is the best way to get the most out of your synbiotic. By signing up for a subscription, you’ll easily be able to build DS-01® into your routine.

    But we want you to feel good about what you’re taking. That’s why we want you to try DS-01®, risk-free for 30 days. You may also reschedule or cancel your subscription easily from your account at any time.

    What does my subscription to DS-01® Daily Synbiotic include?

    Your monthly subscription includes a 30-day supply of DS-01®. Your first month’s shipment is your Welcome Kit. It includes a reusable glass jar holding your first month’s supply, some Seed reading materials, and a complimentary travel vial that holds a week’s worth of your DS-01®, so you never miss a day on the go.

    Is DS-01® Daily Synbiotic compatible with my diet or dietary restrictions?

    DS-01® is tested for: Dairy, Gluten, Soy, GMOs, Nuts, Shellfish, Sesame, Glyphosate/AMPA, and 14 classes of allergens defined by European Food and Safety Authority (EFSA)

    It adheres to the following diets: Vegan • Vegetarian • Ketogenic • Gluten-Free • Intermittent Fasting

    What is your 30 day risk-free guarantee? Do you accept returns?

    If for any reason you are not satisfied with your purchase, you may request a refund within 30 days of delivery of your first order. We’ll refund you for the full cost of the product less shipping, VAT, and duties—no questions asked. Refunds apply to your first order only, not any subsequent shipments. For all subsequent shipments, you may reschedule or cancel at any time in your account.

    Note that Sustainable Refill Program orders are considered final sale 30 days after delivery.

    Is DS-01® Daily Synbiotic safe to take while I'm pregnant or breastfeeding?

    As with any dietary supplement or new health protocol contemplated during pregnancy or lactation, we recommend speaking with your physician or obstetrician before you start consuming DS-01® Daily Synbiotic.

    Probiotics, in general, do not appear to pose any safety concerns for pregnant and lactating individuals. The current literature does not indicate an increase in adverse pregnancy outcomes when probiotics are used by healthy individuals.

    Do you ship internationally?

    Yes—we ship to many countries internationally.

    • ★★★★★

      I love the sustainable packaging and convenient shipping. I never run out and don’t have to think about refilling.

      Erin M.

    • ★★★★★

      I have struggled for years with my gut health. I have tried so many products and spent so much money it is insane. Trying DS-01 Daily Synbiotic is the best thing I ever did, it really works.

      Sherri

    • ★★★★★

      I love the sustainable packaging and convenient shipping. I never run out and don’t have to think about refilling.

      Erin M.

    • ★★★★★

      After trying many probiotic brands, seed by far is the hands down the best on the market and my gut has been feeling the best ever since I started seed

      Joe

    • ★★★★★

      I think this is the best probiotic I have taken so far. Really good stuff!

      Jonathan L.

    • ★★★★★

      Seed has helped my GI issues (bloating, sensitivity) since starting. I would recommend seed to anyone I know

      Christine M.